The challenges often arise from the complexity realised in biological settings. Development of scaffolds for tissue engineering and regenerative medicine with an emphasis on the production and characterisation of micro- and nanofunctionalised 3D scaffolds as advances bio active implant materials. Within the concept of Computer Aided Biological Response Assessment CABRA to develop mathematical models of biological activities like disease progression, implant performance, or cellular motility.
In particular, we have studied atherosclerosis and cancer.
Department of Engineering Laboratories. Key publications. Research project Print-on-demand body implants Researchers are giving birth to a new method for the manufacture of bones, cartilage and joints to cure or ease tissue injuries. Biomechanics and Mechanobiology MSc. Biomechanics is a rapidly expanding field that focuses on exploring the mechanics of structure—function relationships underlying the functionality of living systems with the aim of gaining insights for medical applications.
The field cuts across diverse disciplines: physics, biology, medicine, mechanical engineering, and biomedical engineering, and incorporates principles and concepts from these fields in the study of living systems and their dynamics. A major objective of this series is to pioneer new frontiers of biomechanics by including concepts and ideas from new research frontiers yet to be addressed within the existing paradigm of biomechanics. If either of these criteria are met, the plaque is at risk of rupturing and creating a thrombus that will kill the victim.
These changes include increased shear stress in the blood vessels, changes in systolic and diastolic blood pressures, and increased pressure fluctuations in the arteries. Thankfully in our modern age, atherosclerotic plaques can be detected and treated through a variety of methods. Each method has its advantages and disadvantages. Certain procedures excel at identifying atherosclerosis in certain arteries but struggle in other arteries.
It is becoming more common to use noninvasive procedures as they become more advanced. In many cases, they are just as effective as invasive procedures at detecting atherosclerosis. As atherosclerosis becomes more common, research on the disease is expanding. Every year, doctors are becoming more equipped to handle atherosclerosis.
During everyday activities like walking and climbing up stairs, the knee experiences 2. It is a wonder how the knee can withstand so much weight over such a long period of time. Millions of years of evolution and adaptation can be found in the knee as it seems to be built for exactly what humans need it to do. The knee is meant to bear load and help the body move at the same time, and it does just that.
The meniscus not only reduces the friction between our femur and tibia but also reduces the stress felt on the tibia.
Humans often stand for longer periods of time, and the knee has a mechanism to reduce the amount of force needed to stay standing upright. More recently in the field of biomedical engineering, procedures are being developed to fix the issues caused by trauma or simply by degradation. Muscle is a complex tissue that is involved in many processes and systems essential to human life. They are used for balance, stability, movement, organ function, lifting objects, and many other things.
This tissue needs to be analyzed from the smallest unit all the way up to the macroscale of its involvement in complex functions. Furthermore, certain engineering applications and considerations needs to be covered. Through analysis of fundamental structures and functions, the role of the muscle in the body needs to be explored, and its relevance to human life needs to be discussed.
Muscle is a contractile tissue within the body responsible for internal and external locomotion and posture. There are different types of muscle tissue, composed of different types of fibers.
Contractions are stimulated by the nervous system and have a specific need for energy depending on their environment. In addition, adaptations to the structure and function will arise when exposed to stimuli such as exercise.
Muscle is a complex, versatile tissue which provides humans with the ability to execute a variety of tasks. Both muscles as a complex functional group and single muscle fibers as an individual functional unit have been discussed.
The interactions of muscle tissue with the rest of the body perform many different functions that need to be carried out simply and effectively. From the contraction of single muscle fibers all the way to the entire muscle groups working together to complete a movement, the structure and fundamental properties of muscles work cooperatively to fulfill different functions and needs of the body. Proper circulation of blood throughout the body is extremely crucial to a long and healthy life. Any infliction that inhibits the normal flow of blood through the vast network of blood vessels poses an extreme risk to patients and can cause numerous potentially fatal conditions depending on their location.
Find Rare Books Book Value. Skip to main content. Grade Descriptors are available which provide a general guide to the standard of work that is expected at each grade level. Mechanotransduction is a developing multidisciplinary area that embraces cell and developmental biology, biomaterials, biochemistry, biomedical engineering, and medical biophysics [ 5 , 6 ]. Mathematical description of data is an important part of tissue mechanics, as is modeling of 3D stress-strain behavior.
Vascular grafts are a surgical method utilized to redirect blood flow from one area to another whether to bypass a clogged or narrowed blood vessel or provide an easy access point for other procedures such as blood dialysis. It is an unfortunate truth that, in their current state, synthetic grafts are not a long-term solution to vascular stenosis and provide only small extensions on expected life spans. With the current state of undesirable compliance mismatch that exists between them and the vessels that they are grafted too, it is clear that there is a lot of room for improvement.
Future research on the use of multicomponent synthetic grafts in which multiple materials are used together to better mimic the elastin and collagen mechanical properties of natural arteries and veins has a potential for improving the compliance of synthetic grafts, which ultimately leads to improved patency over time.
As for tissue engineering, it is being constantly improved upon every single day. The future of biomedical engineering lays in the replication of human tissues through tissue engineering. The only way to correctly mimic the compliance of a human blood vessel is to use a form of tissue engineering.
Many improvements have been made already, with some very promising results as seen in the hybrid scaffold methods as well as the decellularized matrices. It is important to note that the highest potential lies in the assembly processes. These are the processes that will allow for any mechanical property and shape to be designed exactly. Finally the research toward sutures and the anastomotic site is also a very key area. With the hypercompliant zone being so detrimental, it is very important to consider alternate forms of sutures to combat the high compliance mismatch of those areas.
In the future it can be said that a form of biocompatible glue or laser or even a combination of both may be the best choice of suture. In order for this to happen a lot of work needs to be done in those areas in order to formulate techniques in which the negatives previously mentioned are mitigated. This disease may have a variety of causes, such as age, gender, hyperlipidemia, rheumatic fever, hypertension, heart infection, abnormal stresses, and congenital abnormalities.
Due to the extremely invasive nature of open-heart surgery, the mortality rate for older patients is very high, and until these patients would have had to take the risk of open-heart surgery or have no treatment and left to endure cardiac failure.
Henning Rud Andersen invented an alternative surgery to replace the native aortic valve, known as a transcatheter aortic valve replacement TAVR , also known as a percutaneous aortic valve replacement PAVR. This surgery is done by using various catheters and medical imaging machines to allow for a replacement valve to be directed up an artery to the diseased native aortic valve.
The catheter is most commonly inserted into the iliac artery or femoral artery, but there are other methods surgeons use based on their patient.